Eucupin and Eumenol

EUCUPIN (basic), Eucupinum basicum, a derivative of quinine, by chemical composition iso-amylhydrocupreine, C₂₇H₄₀N₂O₂; molecular weight 382.3; a colorless powder, odorless, almost tasteless; insoluble in water, easily soluble in alcohol, ether, chloroform, essential and fatty oils. It possesses a strong bactericidal effect on various cocci and the diphtheria bacillus; it also possesses a local anesthetic effect. It is rarely used internally: 0.25–0.5 g several times a day. Side effects: urinary tract issues, tinnitus, visual disturbances. Externally, Eucupin is used as a local anesthetic in a 1–3% oil solution for anesthesia of the bladder in tuberculosis, in 2–5% ointments for ulcerated carcinomas, and in 2% suppositories for proctitis; as an antiseptic, it is used in the treatment of diphtheria, for the sterilization of diphtheria bacillus carriers, for Plaut-Vincent angina, and for injection into abscesses in a 0.5–1% solution. Eucupin hydrochloride dissolves in 15 parts of water and easily in alcohol. It is used in the same cases and in the same dosage as basic Eucupin.

EUMENOL, an extract from the root of tang-kui (tang-kuei) (Angelica anomala chinensis, China); a brownish-yellow liquid, with a bitter-aromatic taste and an acidic reaction. In Chinese medicine, the tang-kui root is used as an emmenagogue that does not have an abortifacient effect. In experiments on dogs, Eumenol causes a lowering of blood pressure and contraction of the uterus, bladder, and intestinal musculature. The active principle has not been determined. It is administered in tablets of 0.3–0.5 g, 2–4 tablets for amenorrhea, mainly of neurogenic origin.