Tenosin
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Tenosin is a pharmaceutical preparation composed of histamine and tyramine, historically used as a substitute for ergot. It acts more rapidly than ergot but has a shorter duration of effect.
Encyclopedia entry (1928–1936)
Tenosin, a preparation consisting of histamine and tyramine, used in medical practice as a substitute for ergot. Tenosin is a sterile liquid containing 0.000125 g of histamine and 0.00625 g of tyramine per 1 cm3, to whose pharmacodynamic properties Tenosin owes its application. Its effect begins more rapidly than that of ergot, but it ceases more quickly. Dosage: orally, 20 drops three times a day; subcutaneously or intramuscularly, 1 cm3 several times a day. Side effects are rare: headache, nausea, vomiting. Intravenous injection is impermissible.
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“Tenosin.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.com/article/tenosin/