Thiosinamine
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Thiosinamine is an allylthiourea compound historically used to soften and loosen scar tissue. It was administered topically, orally, or via injection for conditions such as post-burn scars, lupus, and strictures, though it could cause side effects like rashes and fever.
Encyclopedia entry (1928–1936)
THIOSINAMINE, Thiosinaminum, allylthiocarbamide, allylthiourea, NH2CSNH.CH2.CH:CH2. Colorless crystals with a faint, garlic-like odor and a bitter taste, melting at 74°. It dissolves easily in water, alcohol, and ether. Thiosinamine causes the infiltration of scar tissue with serous exudate and the accumulation of leukocytes, which leads to the softening and loosening of the scar tissue. Side effects: burning at the injection site, rash, and increased temperature, especially in tuberculous patients. It is used externally for scars after burns, for lupus, for postoperative adhesions, and for strictures of the esophagus, auditory canal, etc. It is prescribed internally in doses of 0.03–0.1 for articular rheumatism. It is administered subcutaneously and intramuscularly in a 10% glycerin solution to remove scar tissue. It is a component of fibrolysin (see).
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“Thiosinamine.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.com/article/thiosinamine/